中國藥理學(xué)與毒理學(xué)雜志(2016年10期)
Chinese Journal of Pharmacology and Toxicology

目 錄

• 國際合作助推青年人才成長——“中國藥理學(xué)會-施維雅青年藥理學(xué)工作者獎”設(shè)立20周年
• 先導(dǎo)物發(fā)現(xiàn)的新方法（英文）
• 健康與疾病狀態(tài)下腦部鈣信號傳導(dǎo)（英文）
• 一氧化氮研究三十年:自優(yōu)而劣（英文）
• 二甲雙胍藥代動力學(xué)與藥效學(xué)的個體差異（英文）
• 阿拉斯加原住民藥物基因組學(xué)發(fā)現(xiàn)與臨床相關(guān)性（英文）
• 從神經(jīng)元的分子調(diào)控到認(rèn)知與記憶（英文）
• 運(yùn)動皮質(zhì)的塑性:多巴胺的神經(jīng)分布（英文）
• AngⅡ誘導(dǎo)兔動脈粥樣硬化下肢再狹窄磷酸化JAK/STAT信號傳導(dǎo)調(diào)控機(jī)制的實驗研究
• 阿司匹林和氯吡格雷聯(lián)合應(yīng)用致急性心肌梗死后大鼠胃黏膜損傷和微血管變化的藥理機(jī)制初探
• 心肌損傷修復(fù)過程中的細(xì)胞交互作用機(jī)制研究
• DRAM1通過改善自噬流抗心肌缺血損傷
• 川穹嗪對腎性高血壓大鼠心肌重構(gòu)及P38MAPK/AP-1信號通路的影響
• 硫化煙酸對血管內(nèi)皮細(xì)胞損傷模型的保護(hù)作用
• 白藜蘆醇通過調(diào)節(jié)PGC-1α活性與線粒體功能抑制多柔比星心肌細(xì)胞損傷
• 轉(zhuǎn)化生長因子β_1/Smad信號通路在肺動脈高壓中的作用
• 甜菜堿對大鼠心肌肥厚的保護(hù)作用及機(jī)制
• 內(nèi)皮祖細(xì)胞對實驗兔動脈粥樣硬化再狹窄模型調(diào)控功能的研究
• Salvianolic acid A attenuates isoproterenol-induced myocardial infarction in mice through PI3K/Akt signal pathway
• Caffeoylquinic acid derivatives extract of Erigeron multiradiatus alleviated acute myocardial ischemia reperfusion injury in rats through inhibiting NF-kappaB and JNK activations
• The role of HSPB1 and ectopic F1Fo-ATPase interaction in hypoxia pulmonary hypertension vascular adventitial vasa vasorum remodeling
• Effects of hydrogen-rich saline on platelet activation in hypertensive rats
• DDAH1-V3 transcript might act as miR-21 sponge to maintain balance of DDAH1-V1 in cultured HUVECs
• J24924 possesses cardiovascular and renal protective effects on pristane-induced lupus through inhibition of RhoA/Rho kinase pathway in mice
• UCN enhances TGF-β-mediated mitoinhibition of VSMCs via counteracting TGF-β-induced cPLA2 expression and activation
• Calpain mediated pulmonary vascular remodeling in hypoxia induced pulmonary hypertension
• Ginkgolide K protects the heart against ER stress injury by activating the IRE1α/XBP1 pathway
• Cerebral vasorelaxant material basis of Xiaoxuming decoction study with rat basilar artery
• Regulation of microRNAs in cell signaling pathways-mediated vascular remodeling
• DL0805 derivatives protect the pulmonary arterial cells via the RhoA/ROCK pathway
• Salvianolic acid A attenuates vascular remodeling in a pulmonary arterial hypertension rat model
• 毒品的神經(jīng)免疫藥理學(xué)及創(chuàng)新藥物發(fā)現(xiàn)
• 質(zhì)量標(biāo)準(zhǔn)化的紅花黃酮類提取物抗帕金森病的藥效學(xué)評價
• 間苯三酚類衍生物WYD1-8抑制神經(jīng)炎癥作用機(jī)制的研究
• 百可利對魚藤酮致帕金森病模型的神經(jīng)保護(hù)作用
• 百可利對魚藤酮誘導(dǎo)的帕金森病模型大鼠腦組織抗氧化能力的影響
• MPTP致慢性帕金森病小鼠模型的潛在生物標(biāo)記物及藥物靶點(diǎn)的研究
• 蒙藥嘎日迪-13對腦缺血損傷大鼠MPO表達(dá)的影響
• 丁苯酞的抗焦慮作用及機(jī)制研究
• 癲癇發(fā)作和抗癲癇藥物誘導(dǎo)共同導(dǎo)致耐藥性癲癇腦中P-糖蛋白過表達(dá)
• 以Nampt/SIRT1為靶點(diǎn)探索通絡(luò)醒腦泡騰片抗氧化應(yīng)激作用
• 桃紅四物湯對魚藤酮誘導(dǎo)帕金森細(xì)胞模型保護(hù)作用
• 紅景天苷促大鼠腦缺血再灌注腦組織的神經(jīng)再生作用
• 丹酚酸A對大鼠腦缺血再灌注損傷的保護(hù)機(jī)制
• DL0410改善APP/PS1轉(zhuǎn)基因小鼠學(xué)習(xí)記憶的作用機(jī)制
• 銀杏二萜內(nèi)酯對缺血再灌注大鼠腦組織中神經(jīng)遞質(zhì)的影響
• DL0410對APP/PS1轉(zhuǎn)基因小鼠的神經(jīng)保護(hù)作用
• 兩種線粒體復(fù)合體抑制劑擬PD動物模型的建立及行為學(xué)檢測
• 匹諾塞林對大鼠腦梗死后rtPA誘導(dǎo)的出血性轉(zhuǎn)化的預(yù)防作用及機(jī)制
• 復(fù)方柴歸方抗抑郁藥效學(xué)特點(diǎn)
• 培元解郁方對急慢性應(yīng)激BALb/c小鼠的抗抑郁作用及TRY-KYN代謝途徑的調(diào)節(jié)
• 斯皮諾素誘導(dǎo)小鼠非快動眼睡眠
• 白藜蘆醇抑制星形膠質(zhì)細(xì)胞氧化應(yīng)激的細(xì)胞內(nèi)作用機(jī)制
• BKCa通道在適度酒精預(yù)適應(yīng)保護(hù)腦缺血再灌注損傷中的作用及ROS的調(diào)控機(jī)制
• 以炎癥為靶點(diǎn)治療慢性缺血后的腦白質(zhì)損傷
• Neuroprotective effect of Angiopep-2 peptide modified scutellarin-loaded PEGylated PAMAM dendrimer nanoparticles on ischemic stroke by modulating the Toll-like receptors-dependent MyD88/IKK/NF-κB signaling pathway
• The neuroprotective effect of Rhodiolae on dementia rat induced by ibotenic acid
• Lentivirus-mediated knockdown of phosphodiesterase 4D improved depression-like behaviors in mice
• Melatonin alleviates lipopolysaccharide-compromised integrity of blood brain barrier by activation of AMP-activated protein kinase in old mice
• Propane-2-sulfonic acid octadec-9-enyl-amide,a novel PPARα/γ dual agonist,protects against ischaemiainduced brain damage in mice by inhibiting inflammatory responses
• The effects of 5-lipoxygenase inhibitor and cysteinyl leukotriene receptor 1 antagonist on 1-methyl-4-phenylpyridine-induced neurotoxicity
• Attenuation of Scutellaria barbata flavonoids on cortical cytoplasm apoptotic factors disorders induced by complex Aβ_(25-35) in rats
• Moderate alcohol preconditioning activates BKCa channels to protect brain damage-induced by cerebral ischemia and reperfusion
• Isoliquiritigenin suppresses microglial activation and neuroinflammation in primary microglia
• Inhibition of chemokine-like factor 1 improves bloodbrain barrier dysfunction in rats following focal cerebral ischemia
• Hippocampal PPARδ downregulation contri butes to depressive phenotype with decreased neurogenesis
• Adenosine A2A receptor-expressing neurons in the striatum regulate sleep behaviors
• Natural product compound 3c ameliorates brain inflammation and brain ischemic stroke via AMPK-mediated microglia polarization
• Modulation of abnormal neuronal circuit in temporal lobe epilepsy
• The basic helix-loop-helix(bHLH)transcription factor,DEC1,provides neuroprotection from apoptosis induced by MPP~+ through PI3K/Akt pathway in SHSY5Y cells
• Mechanical allodynia and affective behavior are improved by INI-0602,a gap junction hemichannel inhibitor,in a rat model of neuropathic pain induced by sciatic nerve injury
• Synergistic use of geniposide and baicalin on BV2 cell activation damage caused by LPS
• Neuroprotective effects of kaempferol against 2VO-induced chronic cerebral ischemia in rats
• Xiao-xu-ming decoction inhibits lipopolysaccharide induced neuroinflammation in mice
• The extract of Ramulus Cinnamom attenuates inflammatory injury induced by LPS via regulation of TLR4/MyD88 signaling pathway in BV2 cells
• Ginkgo biloba extract-761 improves the motor functions in permanent middle cerebral artery occlusion rats
• Chemogenetic activation of sublaterodorsal tegmental glutamatergic neurons alleviates rapid eye movement sleep behavior disorder symptoms in a chronic rat model of Parkinson disease
• 人參地黃桑葚片對小鼠免疫功能的影響
• 利用斑馬魚模型研究姜黃素抗炎的分子機(jī)制
• 雙環(huán)醇抗炎作用機(jī)制研究
• 蝦青素對博來霉素致大鼠肺纖維化的干預(yù)作用及機(jī)制
• 炎癥免疫反應(yīng)軟調(diào)節(jié)—藥物研究新方向
• 二仙膏對化療后白細(xì)胞減少癥的藥效作用
• 不同提取方法及給藥途徑的腸腑康膠囊對大鼠脾虛型潰瘍性結(jié)腸炎的影響
• 白虎加桂枝湯對熱痹模型大鼠特征性甲基化基因表達(dá)的影響
• 雷公藤內(nèi)酯醇LLDT-8在抗GBM抗體誘導(dǎo)小鼠腎炎中的療效作用及對Fc受體介導(dǎo)淋巴細(xì)胞活化的調(diào)控機(jī)制
• DL1502新晶型對骨關(guān)節(jié)炎模型的治療作用
• 神經(jīng)酰胺類鞘脂及其代謝通路參與免疫性肝纖維化發(fā)生發(fā)展的作用研究
• 構(gòu)樹果汁體外抗氧化及對小鼠免疫調(diào)節(jié)作用
• 清除衰老細(xì)胞治療小鼠放射性肺纖維化機(jī)制
• 異甘草酸鎂對小鼠放射性肺纖維化的改善作用及其機(jī)制的初步探討
• Interaction of Wnt/β-catenin and Nrf2 pathways in cigarette smoke-induced inflammation and emphysema
• Nrf2 inhibits epithelial-mesenchymal transition by suppressing snail expression during pulmonary fibrosis
• Anti-inflammatory effect of extracts of Dendropanax dentige and Lycopodiastrum casuarinoides on rheumatoid arthritis and their underlying mechanism in rats
• Increased BAFF in serum is a novel biomarker related to disease activity in rheumatoid arthritis
• Matrine ameliorates experimental autoimmune encephalomyelitis by regulating the differentiation of encephalitogenic Th1/Th17 and Th2/regulatory T cells
• Mechanism of TSCS promote anti-Fas antibody-induced FLS apoptosis via blocking MC-tryptase-PAR-2-Rho-FLS signaling pathway
• The GSK3b sensing metabolism controls NLRP3 inflammasome activation
• Curcuma′s extraction attenuates propranolol-induced psoriasis like in mice by inhibition of keratin,proliferating cell nuclear antigen and Toll-like receptor expression
• Salvianolic acid A alleviates renal injury in systemic lupus erythematosus induced by pristane in BALB/c mice
• 臨床常用普伐他汀鈉片大鼠體內(nèi)藥代動力學(xué)比較研究
• 孕三烯酮膠囊多次給藥在巴馬小型豬體內(nèi)的藥代動力學(xué)研究
• KCNQ鉀通道在糖尿病神經(jīng)病理性疼痛中的作用及機(jī)制研究
• 采用雙向驗證法和斑馬魚模型探索血管生成相關(guān)的內(nèi)源性代謝物及代謝網(wǎng)絡(luò)的變化
• 液質(zhì)聯(lián)用法同時測定新西蘭兔血漿中左炔諾孕酮和炔雌醇及其藥動學(xué)
• 基于~1H-NMR代謝組學(xué)技術(shù)研究D-半乳糖致衰老大鼠尿液的動態(tài)變化
• 抗癲癇新藥氯桂丁胺與藥物代謝酶CYP450的相互作用
• 性激素對二乙基亞硝胺(DEN)所致肝癌組織中CYP450酶表達(dá)的影響
• 新型利尿藥PU-48在生物樣本中LC-MS/MS檢測方法的建立與確證
• 基于~1H-NMR代謝組學(xué)的黃芩素干預(yù)D-半乳糖致衰老大鼠作用研究
• 杜仲降血壓活性成分在正常大鼠和自發(fā)性高血壓大鼠體內(nèi)的藥代動力學(xué)差異研究
• 伏立康唑血藥濃度監(jiān)測結(jié)果評析
• 細(xì)胞外Ba~(2+)對記錄大鼠心肌細(xì)胞L型鈣通道的影響
• Inhibitory effect of plumbagin,a potential anticancer natural compound,on cytochrome P450 2J2 in humans
• Review on the effects of the traditional Chinese medicine on cytochrome P450
• Pharmacokinetic parameters investigation on interaction between Danshen injection and Honghua injection
• Microdosing cocktail study on the determination and pharmacokinetics of six hepatic cytochrome probes and their metabolites in rat
• Translational regulation of RPA2 via IRES by UNR and e IF3a
• The anti-nociceptive effect of bufalin,an active ingredient from toad venom via modulating voltage-gated sodium channels
• MLKL forms cation channels
• Characteristics and pharmacokinetics of tripterygium glycosides nano-carries transdermal delivery systems:skin-blood synchronous microdialysis and numerical simulation
• A genome-wide association study identifies novel genetic loci that modify pharmacokinetic-pharmacodynamic responses to clopidogrel
• Generation and characterization of a novel CYP3A1/2 double knockout rat model using CRISPR-Cas9 system
• Histone methylation and acethylation contribute to rifampin-mediated induction of CYP3A4 through the interactions between PXR and NCOA6/p300
• TMEM16A contributes to endothelial dysfunction through accelerating Nox2 NADPH oxidase-derived ROS generation in hypertension
• Effects of FOXO1 mediated regulation of mitochondrial function in diabetic wound healing
• Translational regulation of DNA repair systems by eIF3a in cancer chemotherapeutic response
• 長效GLP-1類似物HYHN抗糖尿病藥理作用評價
• 高表達(dá)Sptlc2基因促油酸誘導(dǎo)的HSC-T6細(xì)胞凋亡及自噬
• Sirt1在高糖刺激腎小球微血管內(nèi)皮細(xì)胞損傷中的作用
• 依帕司他對2型糖尿病大鼠肝纖維化的影響
• 利拉魯肽對糖尿病大鼠腎損傷過程中MyD88蛋白表達(dá)及炎癥因子的影響
• 孕期炎癥刺激致子代大鼠血脂異常的機(jī)制初探
• 大黃酸在中毒性腎功能損傷中的保護(hù)作用
• 粗壯女貞總苷降血脂作用及其基于AMPK通路的降脂作用機(jī)制
• 茶黃素降低黃嘌呤聯(lián)合氧嗪酸鉀誘導(dǎo)高尿酸血癥小鼠的血漿尿酸作用及機(jī)制探究
• 七斛血糖制劑對KK-A~y小鼠降糖作用
• 基于藥理學(xué)和代謝組學(xué)技術(shù)闡明慢性腎衰竭的作用機(jī)制及麥角甾酮抗腎纖維化
• 黃芪甲苷對鏈脲佐菌素誘導(dǎo)糖尿病大鼠腎保護(hù)機(jī)制探討
• 低分子量褐藻多糖硫酸酯改善白蛋白超載引起的腎小管細(xì)胞損傷
• 果糖1,6二磷酸酶抑制劑cpd-36在四氧嘧啶小鼠中的降糖作用研究及機(jī)制初探
• Hepatic NAD~+ deficiency as a therapeutic target for NAFLD in aging
• Apelin/APJ system and kidney disease
• Ameliorative effect of berberine on high-fat diet/streptozotocin-induced early diabetic nephropathy in rats
• Activation of peripheral KCNQ channels relieves gout pain
• Protective effects of total triterpenoids extracts from Cyclocarya paliurus(Batal.)Iljinskaja on STZ-stimulated INS-1 cells through regulating of autophagy and apoptosis
• Berberine enhanced antidiabetic effects and attenuated untoward effects of canagliflozin in streptozotocininduced diabetic mice
• Disruption of hepatic lipid homeostasis is involved in valproate-induced hepatotoxicity
• 雷公藤紅素在乳腺癌中破壞mTOR蛋白穩(wěn)定性的研究
• NO供體藥JS-K對HepG2.2.15細(xì)胞的增殖抑制研究
• NO供體JS-K誘導(dǎo)人肝癌細(xì)胞凋亡及其機(jī)制的研究
• 黃酮類化合物的抗腫瘤作用
• 星形膠質(zhì)細(xì)胞瘤甲基化和非編碼RNA表觀基因組學(xué)研究
• 循環(huán)腫瘤細(xì)胞檢測與腫瘤療效關(guān)系的研究
• 增強(qiáng)型ARMS PCR檢測腦膠質(zhì)瘤中IDH1基因突變方法的建立
• MAL基因的表觀遺傳學(xué)調(diào)控對NSCLC吉非替尼敏感性的影響
• 子宮內(nèi)膜癌藥物治療研究進(jìn)展
• DL1106與doxorubicin和paclitaxel協(xié)同作用及其機(jī)制研究
• 抑制細(xì)胞自噬的三陰性乳腺癌防治新策略
• 2-苯基-3,4-噻二唑[3,2-α]并嘧啶-7-酮(TPh)對人肝癌細(xì)胞HepG2細(xì)胞周期、凋亡及相關(guān)因子表達(dá)的影響
• 基于共晶體結(jié)構(gòu)設(shè)計全新PARP1抑制劑的合成及在三陰性乳腺癌中誘導(dǎo)凋亡機(jī)制的研究
• 新型的eEF2K抑制劑BL-EKI03在乳腺癌中誘導(dǎo)自噬和凋亡作用機(jī)制研究
• 天然多酚化合物對PC9/G細(xì)胞Gef敏感性和MAL基因表達(dá)的影響
• IDH突變通過影響GNG基因表達(dá)而影響低級別腦膠質(zhì)瘤患者預(yù)后
• 腫瘤抑素改造T-7R肽體外抗腫瘤活性研究
• 化瘀丸通過血小板介導(dǎo)的肝素酶途徑對4T1乳腺癌的抑制作用
• 菊苣酸對HL-60誘導(dǎo)的白血病小鼠的治療作用及機(jī)制研究
• 人U87-MG腦膠質(zhì)瘤細(xì)胞裸鼠原位移植模型的建立
• 巨噬細(xì)胞的免疫重塑:防治腫瘤轉(zhuǎn)移的新靶點(diǎn)
• Porous Pt nanoparticles for cancer photothermal therapy
• Dysregulation of metallothionein and circadian genes in human hepatocellular carcinoma
• DNMT3A genetic polymorphisms predict disease prognosis in R882 mutation negative AML patients
• MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1
• Baicalin inhibits cell growth and induces autophagy via AMPK/ULK1 activation in MDA-MB-231 cells
• Carnitine palmitoyl transferase 1C regulates tumor cell senescence
• Gold nanorods for gambogicacid intracellular delivery
• Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase Ⅰ and topoisomerase Ⅱ
• Zeylenone promotes apoptosis of chronic myelogenous leukemia-derived K562 cells by a mechanism involving Jak2 and src kinase
• Spatholobus suberectus column extract inhibit estrogen receptor positive breast cancer
• Gap junctions enhance the antiproliferative effect of microrna-124-3p in glioblastoma cells
• PTEN bridges protective autophagy and apoptosis induced by DNA damage mediated by reactive oxygen species(ROS)in response to cucurbitacin B in hepatocellular carcinoma cells
• Actinomycin D synergistically enhances the efficacy of CDDP by activating P53-PUMA pathway via downregulating P53-MDM2 complex on KB cells
• Resistin contributes to lung adenocarcinoma progression by TLR4/EGFR/PI3K/NF-KB pathway
• In vitro and in vivo evaluation of fisetin as an anticancer agent for breast cancer
• GRK2 overexpression inhibits IGF1-induced proliferation and migration of human hepatocellular carcinoma cells by down-regulating EGR1
• Combination of metformin and curcumin exhibits synergistic inhibitory effects on tumor growth and metastasis in HepG2 cells
• Depletion of PINK1 sensitizes breast cancer cells to polyphyllin Ⅰ via mitophagy suppression and DRP1-mediated mitochondrial fission
• Perspectives on bone-targeted nano-drug carriers for bone tumor treatment
• Enoxaparin sensitizes human non-small-cell lung carcinomasto gefitinib by inhibiting DOCK1 expression,vimentin phosphorylation,and Akt activation
• Effects of garcinone E on ovarian cancer cells:endoplasmic reticulum stress,apoptosis,migration and invasion inhibition
• GubenyiliuⅡ inhibits breast tumor growth and metastasis associated with decreased heparanase expression and Akt phosphorylation
• Different gap junction-propagated effects on cisplatin transfer result in opposite responses to cisplatinin normal cells versus tumor cells
• Gap junctions enhance the antiproliferative effect of microrna-34a in glioma cells
• A polymorphism in GAS5 promoter impacts efficacy of cytarabine-based chemotherapy in Chinese AML patients
• 3-O-(Z)-coumaroyloleanolic acid overcomes Cks1b-induced chemoresistance in lung cancer by inhibiting Hsp90 and MEK pathways
• 山沉香超微粉、原粉與沉香超微粉、原粉藥理學(xué)作用對比研究
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