Acta Pharmaceutica Sinica B(2021年10期)
藥學學報(英文版)

目 錄

• Aims and Scope
• Announcing 2020 Impact Factor for Acta Pharmaceutica Sinica B
• Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development
• CRISPR-Cas9: A method for establishing rat models of drug metabolism and pharmacokinetics
• Alterations of DNA damage response pathway:Biomarker and therapeutic strategy for cancer immunotherapy
• Natural compounds in the regulation of proteostatic pathways: An invincible artillery against stress, ageing, and diseases
• Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson ‘ s disease
• Recent developments in the medicinal chemistry of single boron atom-containing compounds
• Nanomedicine for acute respiratory distress syndrome: The latest application, targeting strategy, and rational design
• MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction
• TRIB3-GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target
• PD0325901, an ERK inhibitor, enhances the efficacy of PD-1 inhibitor in non-small cell lung carcinoma
• Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR
• 3D disorganization and rearrangement of genome provide insights into pathogenesis of NAFLD by integrated Hi-C, Nanopore, and RNA sequencing
• Salmonella flagella confer anti-tumor immunological effect via activating Flagellin/TLR5 signalling within tumor microenvironment
• Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy:Dynamic analysis on cytotoxic effects of LW-218
• Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy
• Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3
• Bioresponsive micro-to-nano albumin-based systems for targeted drug delivery against complex fungal infections
• Tumor microenvironments self-activated nanoscale metal-organic frameworks for ferroptosis based cancer chemodynamic/photothermal/chemo therapy
• Self-assembled FeS-based cascade bioreactor with enhanced tumor penetration and synergistic treatments to trigger robust cancer immunotherapy
• Cancer-specific calcium nanoregulator suppressing the generation and circulation of circulating tumor cell clusters for enhanced anti-metastasis combinational chemotherapy
• Cytosolic delivery of the immunological adjuvant Poly Ⅰ:C and cytotoxic drug crystals via a carrier-free strategy significantly amplifies immune response
• Synchronous conjugation of i-motif DNA and therapeutic siRNA on the vertexes of tetrahedral DNA nanocages for efficient gene silence
• TPGS/hyaluronic acid dual-functionalized PLGA nanoparticles delivered through dissolving microneedles for markedly improved chemo-photothermal combined therapy of superficial tumor
• Functional identification of the terpene synthase family involved in diterpenoid alkaloids biosynthesis in Aconitum carmichaelii
• Construction of acetyl-CoA and DBAT hybrid metabolic pathway for acetylation of 10-deacetylbaccatin Ⅲ to baccatin Ⅲ
• Commentary: PROTACs make undruggable targets druggable: Challenge and opportunity
• Information for Authors